Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells |
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| Authors: | Kestutis Planutis Marina Planutiene Mary Pat Moyer Anthony V Nguyen Cherlyn A Pérez Randall F Holcombe |
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| Institution: | (1) Division of Hematology/Oncology, University of California, Irvine, USA;(2) Incell Corporation, San Antonio, Texas, USA |
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| Abstract: | Background Norrin is a potent Wnt pathway ligand. Aberrant activation of this signaling pathway can result in colon tumors but the role
of norrin-based signaling in the genesis of colon cancer, and its relationship to activation of the pathway by traditional
Wnt ligands, is not defined. |
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