Leptospirosis vaccines |
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Authors: | Zhijun Wang Li Jin Alicja W?grzyn |
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Institution: | (1) CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, PR, China;(2) Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, 200032 Shanghai, PR, China;(3) MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 200433 Shanghai, PR, China;(4) Laboratory of Molecular Biology (affiliated with the University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 80-822 Gdańsk, Poland |
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Abstract: | Leptospirosis is a serious infection disease caused by pathogenic strains of the Leptospira spirochetes, which affects not only humans but also animals. It has long been expected to find an effective vaccine to prevent
leptospirosis through immunization of high risk humans or animals. Although some leptospirosis vaccines have been obtained,
the vaccination is relatively unsuccessful in clinical application despite decades of research and millions of dollars spent.
In this review, the recent advancements of recombinant outer membrane protein (OMP) vaccines, lipopolysaccharide (LPS) vaccines,
inactivated vaccines, attenuated vaccines and DNA vaccines against leptospirosis are reviewed. A comparison of these vaccines
may lead to development of new potential methods to combat leptospirosis and facilitate the leptospirosis vaccine research.
Moreover, a vaccine ontology database was built for the scientists working on the leptospirosis vaccines as a starting tool. |
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