Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH |
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| Authors: | Mathias Norrman Gerd Schluckebier |
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| Affiliation: | 1.Diabetes Protein Engineering,Novo Nordisk A/S,M?l?v,Denmark;2.Molecular Biophysics,Lund University,Lund,Sweden |
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| Abstract: | Background Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the years, insulin has been crystallized and characterized in a number of crystal systems. |
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