Swainsonine production in fed-batch fermentations of Metarhizium anisopliae |
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| Authors: | Manjula S Patrick Maxwell W Adlard Tajalli Keshavarz |
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| Institution: | (1) Biotechnology Division School of Biological and Health Sciences, University of Westminster, 115 New Cavendish Street, W1M 8JS London, UK |
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| Abstract: | Summary Extended and enhanced production of swainsonine was achieved from fed-batch fermentations of the fungus Metarhizium anisopliae. A complex medium based on oatmeal extract was intermittently fed with D-glucose and/or lysine. Swainsonine titres were improved eleven-fold and the duration of production extended was from 240 to 550 hours compared with a batch culture under the same conditions. |
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