Synthesis of multisubstituted quinolines from Baylis-Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity |
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| Authors: | Narender P Srinivas U Ravinder M Rao B Ananda Ramesh Ch Harakishore K Gangadasu B Murthy U S N Rao V Jayathirtha |
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| Institution: | Organic Chemistry Division-II, Indian Institute of Chemical Technology, Tarnaka, Hyderabad. |
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| Abstract: | Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopentag]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-S(N)Ar elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity. |
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