Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease |
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| Authors: | Cl udio R.F. Marinho, Luis N. Nu ez-Apaza, Karina R. Bortoluci, Andr L. Bombeiro, Daniella Z. Bucci, Marcos G. Grisotto, Luiz R. Sardinha, Christian E. Jorquera, Sergio Lira, Maria Regina D'Imp rio Lima,Jos M. lvarez |
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| Affiliation: | aDepartment of Immunology, Biomedical Sciences Institute, University of São Paulo, Av. Professor Lineu Prestes, 1730, São Paulo, SP, CEP-05508-000, Brazil;bDepartment of Biological Sciences, UNIFESP, Diadema, SP, Brazil;cImmunology Institute, Mount Sinai School of Medicine, New York, NY, USA |
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| Abstract: | The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease. |
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| Keywords: | Chagas' disease Trypanosoma cruzi Sylvio X10/4 parasites Parasitaemia Heart pathology Immune response Parasite evasion |
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