Origin and evolution of the vertebrate leukocyte receptors: the lesson from tunicates |
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| Authors: | Ivana Zucchetti Rosaria De Santis Simona Grusea Pierre Pontarotti Louis Du Pasquier |
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| Affiliation: | (1) Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy;(2) LATP UMR 6632 CNRS Evolution biologique et Modélisation, Université de Provence, case 19, 3 place Victor Hugo, 13331 Marseille Cedex 03, France;(3) Institute of Zoology and Evolutionary Biology, University of Basel, Vesalgasse 1, CH, 4051 Basel, Switzerland |
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| Abstract: | Two selected receptor genes of the immunoglobulin superfamily (IgSF), one CTX/JAM family member, and one poliovirus receptor-like nectin that have features of adhesion molecules can be expressed by Ciona hemocytes, the effectors of immunity. They can also be expressed in the nervous system (CTX/JAM) and in the ovary (nectin). The genes encoding these receptors are located among one set of genes, spread over Ciona chromosomes 4 and 10, and containing other IgSF members homologous to those encoded by genes present in a tetrad of human (1, 3 + X, 11, 21 + 19q) or bird chromosomes (1, 4, 24, 31) that include the leukocyte receptor complex. It is proposed that this tetrad is due to the two rounds of duplication that affected a single prevertebrate ancestral region containing a primordial leukocyte receptor complex involved in immunity and other developmental regulatory functions. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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| Keywords: | Linkage Duplication Evolution Tunicates Leukocyte receptors Hemocytes |
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