1. National Institute of Optics, National Research Council (INO‐CNR), Florence, Italy;2. European Laboratory for Non‐Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy;3. +39 055 522 5337+39 055 522 5305;4. Institute of Applied Physics, National Research Council (IFAC‐CNR), Sesto Fiorentino, Italy;5. Light4tech Firenze S.r.l., Scandicci, Italy;6. Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy;7. Department of Physics, University of Florence, Sesto Fiorentino, Italy
Abstract:
The healing process of superficial skin wounds treated with a blue‐LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue‐LED device, while the other two are left to naturally recover. Visual observations, non‐linear microscopic imaging, as well as histology and immunofluorescence analyses are performed 8 days after the treatment, demonstrating no adverse reactions neither thermal damages in both abraded areas and surrounding tissue. A faster healing process and a better‐recovered skin morphology are observed: the treated wounds show a reduced inflammatory response and a higher collagen content.
Blue LED induced photothermal effect on superficial abrasions.
