Minor chromosome variations and selected heteromorphisms in 200 unclassifiable mentally retarded patients and 200 normal controls |
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| Authors: | Avirachan T Tharapel Robert L Summitt |
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| Institution: | (1) Department of Pediatrics, University of Tennessee, Center for the Health Sciences, 711 Jefferson Avenue, 38163 Memphis, Tennessee, USA;(2) Department of Anatomy, University of Tennessee, Center for the Health Sciences, 711 Jefferson Avenue, 38163 Memphis, Tennessee, USA;(3) the Child Development Center, University of Tennessee, Center for the Health Sciences, 711 Jefferson Avenue, 38163 Memphis, Tennessee, USA |
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| Abstract: | Summary Lymphocyte chromosome preparations from 200 mentally retarded children and 200 normal adult controls were analyzed by G-, Q-, and C-banding techniques for minor chromosome variations (G and Q) and selected heteromorphisms (G and C). Minor variations scored included inv(9), prominent or decreased short arms and/or satellite on acrocentric chromosomes, and 17ph. C heteromorphisms analyzed included those involving 1qh, 9qh, and 16qh regions. Length variations of Yq were scored on G-banded karyotypes. No significant differences in frequencies of scored minor variations or heteromorphisms were noted between the retarded and control populations. |
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