Cloning, expression, and characterisation of a Plasmodium vivax MSP7 family merozoite surface protein |
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Authors: | Mongui Alvaro Perez-Leal Oscar Soto Sara C Cortes Jimena Patarroyo Manuel A |
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Affiliation: | Molecular Biology Department, Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia. |
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Abstract: | Plasmodium vivax remains the most widespread Plasmodium parasite species around the world, producing about 75 million malaria cases, mainly in South America and Asia. A vaccine against this disease is of urgent need, making the identification of new antigens involved in target cell invasion, and thus potential vaccine candidates, a priority. A protein belonging to the P. vivax merozoite surface protein 7 (PvMSP7) family was identified in this study. This protein (named PvMSP7(1)) has 311 amino acids displaying an N-terminal region sharing high identity with P. falciparum MSP7, as well as a similar proteolytical cleavage pattern. This protein's expression in P. vivax asexual blood stages was revealed by immuno-histochemical and molecular techniques. |
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Keywords: | Malaria Plasmodium vivax Merozoite MSP7 Vaccine candidate |
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