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Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission
Authors:Boura Evzen  Ró?ycki Bartosz  Chung Hoi Sung  Herrick Dawn Z  Canagarajah Bertram  Cafiso David S  Eaton William A  Hummer Gerhard  Hurley James H
Institution:Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
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  • Highlights? Solution structures of yeast ESCRT-II complex and ESCRT-I-II supercomplex ? ESCRT-I-II has compact, crescent-shaped, and highly extended conformations ? ESCRT-I-II crescent shapes can be docked into a model vesicle bud neck ? Model for coupling of cargo sorting, membrane budding, and membrane scission
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