Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives |
| |
| Authors: | Wang Lisheng You Yejun Wang Songqing Liu Xu Liu Buming Wang Jinni Lin Xiao Chen Mingsheng Liang Gang Yang Hua |
| |
| Affiliation: | School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China. w_lsheng@163.com |
| |
| Abstract: | Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
