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Structural and functional analysis of HtrA1 and its subdomains

Authors:	Eigenbrot Charles Ultsch Mark Lipari Michael T Moran Paul Lin S Jack Ganesan Rajkumar Quan Clifford Tom Jeffrey Sandoval Wendy van Lookeren Campagne Menno Kirchhofer Daniel

Institution:	Department of Structural Biology, Genentech, Inc., South San Francisco, CA 94080, USA.

Abstract:	Download : Download high-res image (216KB) Download : Download full-size image Highlights? IGFBP-like domain structure suggests that it is incompetent for IGF binding ? Kazal-like domain structure shows distorted “P1” loop incompetent for inhibition ? Protease domain shows catalytic readiness in apo form ? SAXS envelope for full-length HtrA1

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