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A unique spatial arrangement of the snRNPs within the native spliceosome emerges from in silico studies

Authors:	Frankenstein Ziv Sperling Joseph Sperling Ruth Eisenstein Miriam

Institution:	Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract:	Download : Download high-res image (350KB) Download : Download full-size image Highlights? We present a computational procedure for fast matching of thousands of conformers ? We obtained a unique model localizing the snRNPs within the native spliceosome ? The 5 snRNPs are accommodated mostly within the large subunit of the spliceosome ? The large spliceosomal cavity emerges as the site of mRNA binding and splicing

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