Effects of human exogenous DNA on production of perforin-containing CD8+ cytotoxic lymphocytes in laboratory setting and clinical practice |
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| Authors: | Alyamkina Ekaterina A Leplina Olga Y Ostanin Alexandr A Chernykh Elena R Nikolin Valeriy P Popova Nelly A Proskurina Anastasia S Gvozdeva Tatiana S Dolgova Evgenia V Orishchenko Konstantin E Rogachev Vladimir A Sidorov Sergey V Varaksin Nikolay A Ryabicheva Tatiana G Bogachev Sergey S Shurdov Mikhail A |
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| Institution: | Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia. |
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| Abstract: | We investigated the influence of Panagen DNA preparations on laboratory animals and IFN-induced human dendritic cells, as well as analyzed the data from a phase II clinical trial in the therapy of breast cancer. It was shown that this treatment resulted in increased number of CD8+/perforin+ T cells in peripheral lymphoid organs of experimental animals, in mixed lymphocyte culture population and in peripheral blood of breast cancer patients. Moreover, we demonstrated that when Panagen DNA preparations are used in combination with the standard FAC-based breast cancer therapies, non-specific immune response activity remains at the same levels as observed prior to therapy, whereas in FAC-placebo patients, non-specific immunity is greatly diminished. |
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