Quantifying slow evolutionary dynamics in RNA fitness landscapes |
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Authors: | Sulc Petr Wagner Andreas Martin Olivier C |
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Affiliation: | Univ Paris-Sud, UMR8626, LPTMS, Orsay, France. petr.sulc@polytechnique.edu |
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Abstract: | We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an inverse power of the evolutionary time. In addition, our study of the trajectories shows that the out-of-equilibrium effects due to the evolutionary process are very weak. In particular, the distribution of genotypes is close to that arising during equilibrium stabilizing selection. As a consequence, the evolutionary dynamics leave almost no measurable out-of-equilibrium trace, only the transition genotypes (close to the border between different periods of stasis) have atypical mutational properties. |
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