Hypoxanthine-guanine phosphoribosyl transferase in brains of mice. Regional distribution in seven inbred mouse strains |
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Authors: | A A Suran |
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Institution: | Division of Neurosciences City of Hope National Medical Center Duarte, California 91010, USA |
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Abstract: | Causal relationships have been suggested between aspects of human behavior and hyperuricemia associated with low tissue activities of the x-linked enzyme hypoxanthine-guanine phosphoribosyl transferase. Brain is reported to have the highest content of HGPRT activity among body organs. Many studies have indicated that genetically distinct strains of mice exhibit strain-specific behavioral phenotypes. The present measurements of HGPRT were made to determine if genetically associated differences in regional distribution of brain HGPRT exist between several inbred mouse strains and if they were of sufficient magnitude to warrant a search for correlations with measures of behavior. Significant differences were found in overall brain content of HGPRT activity among seven inbred mouse strains, as well as in regional distribution of enzyme activity among eight structures of brains of each of the individual strains. |
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Keywords: | Reprint requests should be directed to Secretary Division of Neurosciences City of Hope National Medical Center Duarte California 91010 |
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