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Identification of Mr variants of proclatin with monoclonal antibodies |
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| Authors: | R Aston K Young H van den Berg J Ivanyi |
| Institution: | 1. Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent, England;2. Biochemical Research and Development Laboratories, Organon Scientific Development Group, Oss, The Netherlands |
| Abstract: | Monoclonal antibodies (QB01 and 1200) prepared against human proclatin (hPRL) have helped define a variant form of the hormone. This variant is of apparently higher molecular mass (26kDa) than the predominant form of the hormone (24kDa) and its presence does not appear to be species-restricted. The demonstration of the 26 kDa form of the hPRL in fresh pituitary tissue and amniotic fluid suggests it may retain some specific function. |
| Keywords: | Proclatin Variant Fragment Monoclonal antibody SDS—PAGE Immunoblotting hPRL human proclatin hGH human growth hormone hCS human chorionic somatomammotrophin MAB monoclonal antibody |
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