Lipid peroxidation and fluidity of plasma membranes from rat liver and Morris hepatoma 3924A |
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| Authors: | T. Galeotti S. Borrello G. Palombini L. Masotti M.B. Ferrari P. Cavatorta A. Arcioni C. Stremmenos C. Zannoni |
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| Affiliation: | 1. Institute of General Pathology, Catholic University, Largo F. Vito 1, 00168 Roma, Italy;2. Institute of Biological Chemistry, University of Parma, Viale Gramsci 14, 43100 Parma, Italy;3. Institute of Physics-GNCB, University of Parma, Via D''Azeglio 85, 43100 Parma, Italy;4. Institute of Physical Chemistry, University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy |
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| Abstract: | Plasma membranes isolated from the fast-growing, maximal-deviation, Morris hepatoma 3924A exhibit remarkable changes in lipid composition, lipid peroxidation and to some extent in the physical state with respect to rat liver plasmalemmas. A correlation appears to exit between the lower phospholipid: protein ratio, higher cholesterol: phospholipid ratio, lower rate of lipid peroxidation and decrease in fluidity in tumor plasma membranes. |
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| Keywords: | Hepatoma plasma membrane Lipid peroxidation Lipid composition Membrane fluidity Lipid order Fluorescent probe |
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