Thymidylate synthetase-positive and -negative murine mammary FM3A carcinoma cells as a useful system for detecting thymidylate synthetase inhibitors |
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| Authors: | J Balzarini E de Clercq D Ayusawa T Seno |
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| Institution: | 1. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium;2. Department of Immunology and Virology, Saitama Cancer Center Research Institute, Ina-machi, Saitama-ken 367, Japan |
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| Abstract: | The murine mammary FM3A/O and the thymidylate (dTMP) synthetase-deficient FM3A/TS? carcinoma cell lines can be considered as a novel and useful test system for the detection of nucleoside analogues which are directly aimed at the thymidylate synthetase. These compounds should be inhibitory for FM3A/O but not for FM3A/TS? cells, and their inhibitory effects on FM3A/O cell growth should be readily reversed by exogenous dThd within the concentration range of 5–20 μM. |
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| Keywords: | Murine mammary FM3A carcinoma Thymidylate synthetase 5-Substituted 2'-deoxyuridine analog |
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