Inhibition of testosterone biosynthesis by ethanol: relation to the pregnenolone-to-testosterone pathway |
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Authors: | C.J.P. Eriksson T.V. Widenius P. Leinonen M. Härkönei R.H. Ylikahri |
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Affiliation: | 1. Research Laboratories of the Finnish State Alcohol Company, AIko Ltd, POB 350, SF-00101 Helsinki 10, Finland;2. Department of Clinical Chemistry, University of Oulu, SF-90220 Oulu 22, Finland;3. Department of Clinical Chemistry, University of Helsinki, SF-00290 Helsinki 29, Finland |
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Abstract: | The concentrations of metabolites in the pregnenolone → testosterone pathway were determined in freezestopped testes in control rats and during ethanol intoxication (2 h after injection of 1.5 body wt). Ethanol lowered the mean testicular concentrations of testosterone (by 63–74%), androstenedione (49–81%), 17-hydroxyprogesterone (60–76%), progesterone (29–67%) and pregnenolone (12–25%). 4-Methylpyrazole had no effect on the ethanol-induced changes. The present results reveal no inhibition at the 17-hydroxyprogesterone → androstenedione → testosterone steps, but do not exclude inhibition before the step yielding pregnenolone and at the pregnenolone → progesterone → 17-hydroxyprogesterone steps. |
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Keywords: | Rat Testis Steroidogenesis Testosterone synthesis Ethanol 4-Methylpyrazole |
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