Enhanced casein kinase II activity in human tumour cell cultures |
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Authors: | Katja Prowald Hans Fischer Olaf-Georg Issinger |
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Affiliation: | 1. Institut für Humangenetik, Universität des Saarlandes, D-6650 Homburg-3 FRG;2. Institut für Virusforschung, Deutsches Krebsforschungszentrum D-6900 Heidelberg, FRG |
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Abstract: | Casein kinase II (CKII) activity is enhanced as much as 2–3 fold in established and 4–5-fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells and in established cell lines was reduced to about the same basic level after treatment with heparin, a highly specific inhibitor of CKII activity. The activity of the cAMP-dependent protein kinase was virtually the same in fibroblasts and various human tumour cell lines investigated. |
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Keywords: | Casein kinase Human Tumor cell culture Phosphorylation Transformation |
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