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Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists |
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| Authors: | Witherington Jason Blaney Emma L Bordas Vincent Elliott Richard L Gaiba Alessandra Garton Neil Green Philip M Naylor Antoinette Smith David G Spalding David J Takle Andrew K Ward Robert W |
| Affiliation: | Department of DMPK and Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Jason_Witherington@GSK.com |
| Abstract: | A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists. |
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