Similarities in the mechanisms by which formyl-methionyl-leucyl-phenylalanine, arachidonic acid and leukotriene B4 increase calcium and sodium influxes in rabbit neutrophils |
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| Authors: | T F Molski P H Naccache P Borgeat R I Sha'afi |
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| Institution: | 1. Department of Physiology University of Connecticut Health Center Farmington, CT 06032 USA;2. Department of Pathology University of Connecticut Health Center Farmington, CT 06032 USA;3. Centre de Recherches en Endocrinologie Moleculaire Le Centre Hospitalier de l''Universite Laval Sainte-Foy, Quebec, Canada |
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| Abstract: | The chemotactic factors f-Met-Leu-Phe, arachidonic acid and leukotriene B4 induce a rapid stimulation of both Ca2+ and Na+ influx in rabbit neutrophils. In the three cases the stimulation is rapid and the effects are not additive. Furthermore in all cases the stimulation of Na-influx but not of Ca-uptake is inhibited by the potassium-sparing diuretic amiloride. Preincubation with high concentrations of the chemotactic factor f-Met-Leu-Phe followed by washing of rabbit neutrophils reduces significantly the stimulation of calcium uptake induced by arachidonic acid, leukotriene B4 and f-Met-Leu-Phe. These results strongly suggest that the exogenous addition of arachidonic acid or of leukotriene B4 leads to the activation of the same permeation pathways as do better defined chemotactic factors. |
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