Adherence and motility characteristics of clinical Acinetobacter baumannii isolates |
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Authors: | Eijkelkamp Bart A Stroeher Uwe H Hassan Karl A Papadimitrious Michael S Paulsen Ian T Brown Melissa H |
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Affiliation: | School of Biological Sciences, Flinders University, Adelaide, SA, Australia. |
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Abstract: | Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells. |
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