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Separation and quantitation ofcis- andtrans-thiothixene in human plasma by high-performance liquid chromatography |
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| Authors: | Stuart C Bogema N Narasimhachari Mohammad Mumtaz Savely Goldin Robert O Friedel |
| Institution: | Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298U.S.A. Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298U.S.A. |
| Abstract: | A high-performance liquid chromatographic procedure is described for the separation ofcis andtrans isomers of thiothixene, a thioxanthene derivative used as an antipsychotic agent. A radial compression module (RCM-100) was used with both silica and cyanopropyl cartridges. A fixed-wavelength UV detector (254 nm) was used in these studies for quantitation. Mesoridazine is used as an internal standard because of its separation characteristics and reproducible quantitation. C18 Sep-Pak cartridges are used for biological sample cleanup. Plasma samples from patients treated with thiothixene (Navane) were assayed forcis andtrans-thiothixene. Notrans-thiothixene was detectable andcis-thiothixene concentrations ranged from 0 to 22.5 ng/ml. |
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