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Insertion site of the locus of enterocyte effacement in enteropathogenic and enterohemorrhagic Escherichia coli differs in relation to the clonal phylogeny of the strains |
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| Authors: | Lothar H Wieler Timothy K McDaniel Thomas S Whittam James B Kaper |
| Affiliation: | Center for Vaccine Development, School of Medicine, University of Maryland, 685 W. Baltimore St., Baltimore, MD 21201, USA;Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, Frankfurter Str. 89, 35392 Giessen, Germany;Department of Microbiology and Immunology, Stanford University, School of Medicine, Stanford, CA 94305, USA;Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, PA 16802, USA |
| Abstract: | The locus of enterocyte effacement pathogenicity island confers the attaching and effacing histopathology on epithelial cells infected with enteropathogenic and enterohemorrhagic Escherichia coli. We investigated the site of insertion of the locus of enterocyte effacement in E. coli strains in relation to their evolution based on conservation of housekeeping proteins in these strains. The results indicate that the insertion site of the locus of enterocyte effacement varies according to the evolutionary lineage, suggesting that it has inserted at multiple times and sites during the evolution of these pathogens. |
| Keywords: | Pathogenicity island Locus of enterocyte effacement Enteropathogenic Escherichia coli Enterohemorrhagic Escherichia coli Evolution |
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