Rhodanine derivatives as inhibitors of JSP-1 |
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Authors: | Cutshall Neil S O'Day Christine Prezhdo Marina |
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Affiliation: | Ceptyr Inc., 3830 Monte Villa Parkway, Suite 200, Bothell, WA 98021, USA. ncutshall@ceptyr.com |
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Abstract: | Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders. |
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