Changes in fatty acyl chains of phospholipids induced by interferon in mouse sarcoma S-180 cells |
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| Authors: | K Chandrabose P Cuatrecasas R Pottathil |
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| Institution: | Department of Molecular Biology Wellcome Research Laboratories Burroughs Wellcome Co. Research Triangle Park, North Carolina 27709 USA;Department of Pediatrics University of Maryland School of Medicine Baltimore, MD 21201 USA |
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| Abstract: | S-180 mouse sarcoma cells exhibit antiviral and antiproliferative responses to mouse β interferon. The composition of cellular phospholipids was specifically altered as a result of treatment with interferon. The unsaturated fatty acid content of all of the major phospholipids was decreased, resulting in an increase in the relative proportions of the saturated acyl side chains. These changes can be prevented by anti-interferon antibody and they are not observed with human interferon. |
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