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A novel efficient dynamic programming algorithm for haplotype block partitioning |
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| Authors: | J. Zahiri A. Nowzari-dalini H. Ahrabian |
| Affiliation: | a Center of Excellence in Biomathematics, School of Mathematics, Statistics, and Computer science, University of Tehran, Tehran, Iran b Departments of Bioinformatics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran c National Institute of Genetic Engendering and Biotechnology, Tehran, Iran d School of Computer Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran |
| Abstract: | In this paper, a new efficient algorithm is presented for haplotype block partitioning based on haplotype diversity. In this algorithm, finding the largest meaningful block that satisfies the diversity condition is the main goal as an optimization problem. The algorithm can be performed in polynomial time complexity with regard to the number of haplotypes and SNPs. We apply our algorithm on three biological data sets from chromosome 21 in three different population data sets from HapMap data bulk; the obtained results show the efficiency and better performance of our algorithm in comparison with three other well known methods. |
| Keywords: | Genomics Haplotype diversity SNP Tag SNP |
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