A folding “framework structure” of Tetrahymena group I intron |
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Authors: | Xi Zhang Chen Guo Wen Zhang Huai Cao Kan Wang |
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Affiliation: | a Modern Biological Research Center, Yunnan University, Kunming 650091, China b Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China c Department of Cell Biology and Genetics, Kunming Medical College, Kunming 650031, China d Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, China e Center of Theoretical Biology, Peking University, Beijing 100871, China |
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Abstract: | We have published the dynamic extended folding (DEF) method, which is a RNA secondary structure prediction approach—to simulate the in vivo RNA co-transcriptional folding process. In order to verify the reliability of the method, we selected the X-ray-determined Tetrahymena group I intron as a sample to construct the framework of its folding secondary structure. Our prediction coincides well with the secondary structure predicted by T.R. Cech and the X-ray diffraction crystal structure determined by Lehnert V. Our results show that the DEF framework structure of Tetrahymena group I intron reflects its function sites in a concise and straightforward manner, and the scope of the simulation was expanded. |
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Keywords: | Ribozyme Splice site Dynamic extended folding RNA secondary structure |
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