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A spatial model of cellular molecular trafficking including active transport along microtubules |
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| Authors: | A. Cangiani |
| Affiliation: | a Dipartimento di Matematica e Applicazioni, Università di Milano Bicocca, via Cozzi, 53; I-20125 Milano, Italy b Istituto per le Applicazioni del Calcolo “Mauro Picone”, Consiglio Nazionale delle Ricerche c/o Department of Mathematics, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 1; I-00133 Roma, Italy |
| Abstract: | We consider models of Ran-driven nuclear transport of molecules such as proteins in living cells. The mathematical model presented is the first to take into account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The model is tested by numerical simulations based on discontinuous Galerkin finite element methods. The numerical experiments are compared to the behavior observed experimentally. |
| Keywords: | Signal transduction Intracellular transport Protein motors Microtubules Discontinuous Galerkin methods |
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