New method for comparing DNA primary sequences based on a discrimination measure |
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Authors: | Jie Feng Yong Hu Aibing Zhang |
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Affiliation: | a School of Mathematical Sciences, Capital Normal University, Beijing 100048, China b Institute of Mathematics and Interdisciplinary Science, Capital Normal University, Beijing 100048, China c College of Life Sciences, Capital Normal University, Beijing 100048, China |
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Abstract: | We introduce a new approach to compare DNA primary sequences. The core of our method is a new measure of pairwise distances among sequences. Using the primitive discrimination substrings of sequence S and Q, a discrimination measure DM(S, Q) is defined for the similarity analysis of them. The proposed method does not require multiple alignments and is fully automatic. To illustrate its utility, we construct phylogenetic trees on two independent data sets. The results indicate that the method is efficient and powerful. |
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Keywords: | Pairwise distance Similarity analysis Phylogenetic tree |
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