Self-ligating RNA sequences on the antigenome of human hepatitis delta virus. |
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| Authors: | L Sharmeen M Y Kuo J Taylor |
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| Affiliation: | Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111. |
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| Abstract: | A 179-base fragment of RNA from the 1,679-base antigenome of hepatitis delta virus can not only self-cleave but, when the ends of the resultant fragments are brought into apposition by base pairing to another RNA, also self-ligate. Thus, processing events needed for genome replication in vivo may be strictly RNA mediated. |
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