Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus |
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| Authors: | I A Parshikov J P Freeman J O Lay Jr J D Moody A J Williams R D Beger J B Sutherland |
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| Institution: | (1) National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA, US |
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| Abstract: | To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts
were analyzed by liquid chromatography. The two metabolites (26% and 15% of the A
280, respectively) were identified by mass and 1H nuclear magnetic resonance spectra as N-acetylsarafloxacin and desethylene-N-acetylsarafloxacin. The biological formation of desethylene-N-acetylsarafloxacin has not been previously observed. Journal of Industrial Microbiology & Biotechnology (2001) 26, 140–144.
Received 08 May 2000/ Accepted in revised form 03 November 2000 |
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| Keywords: | : biotransformation fluoroquinolones Mucor ramannianus sarafloxacin |
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