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An approach to heterobifunctional poly(ethyleneglycol) bioconjugates |
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| Authors: | Li Jane Crasto Curtis F Weinberg James S Amiji Mansoor Shenoy Dinesh Sridhar Srinivas Bubley Glenn J Jones Graham B |
| Institution: | aBioorganic and Medicinal Chemistry Laboratories, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA bDepartment of Pharmaceutical Sciences, Northeastern University, USA cDepartment of Physics, Northeastern University, USA dBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA |
| Abstract: | A family of differentially substituted poly(ethyleneglycol) building blocks has been assembled from commercially available material. Their utility is demonstrated by formation of amino acid conjugates, image contrast agents, gold nanoparticles, and functional antibody conjugates. Application in the cellular trafficking of antitumoral agent conjugates is expected. |
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