d-Aminoaciduria in mutant mice lackingd-amino-acid oxidase activity |
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Authors: | R Konno M Ikeda A Niwa Y Yasumura |
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Institution: | (1) Department of Microbiology, Dokkyo University School of Medicine, 321-02 Mibu, Tochigi, Japan;(2) Department of Laboratory of Medical Sciences, Dokkyo University School of Medicine, 321-02 Mibu, Tochigi, Japan |
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Abstract: | Summary Urine of mutant ddY/DAO– mice lackingd-amino-acid oxidase activity contained more serine and proline than that of normal ddY/DAO+ mice.d-Amino-acid oxidase treatment of urinary amino acids decreased the serine and proline, suggesting that they containedd-isomers. An HPLC analysis confirmed the presence ofd-serine. Urinary serine and proline contents were not decreased when the ddY/DAO– mice were fed a diet which did not contain supplementaryd-methionine or when they were given water containing antibiotics. These results suggest that thed-serine andd-proline do not derive from thed-methionine supplemented in the diet or from intestinal bacteria. In urine of the ddY/DAO– mice, a substance which seemed to bed-methionine sulfoxide and/ord-methionine sulfone was present. It is probably a metabolite of thed-methionine supplemented in the diet. Thed-aminoaciduria in the mutant mice lackingd-amino-acid oxidase activity indicates that this enzyme is involved in the metabolism of thed-amino acids in normal mice. |
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Keywords: | Amino acids d-Amino-acid oxidase" target="_blank">d-Amino-acid oxidase d-Aminoaciduria" target="_blank">d-Aminoaciduria Physiological role Mutant mice d-Amino acids" target="_blank">d-Amino acids Urine |
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