Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities |
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Authors: | Spasova Maya Philipov Stefan Nikolaeva-Glomb L Galabov A S Milkova Ts |
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Institution: | South-West University, Neofit Rilski, Blagoevgrad 2700, Bulgaria. |
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Abstract: | The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups. |
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