Functional homology between E. coli ribosomal protein L11 and B. megaterium protein BM-L11 |
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Authors: | Michael J R Stark Eric Cundliffe Jan Dijk and Georg Stöffler |
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Institution: | (1) Department of Biochemistry, Adrian Building, University of Leicester, University, Road, LE1 7RH Leicester, England;(2) Max Planck Institut für Molekulare Genetik, Abt. Wittmann, Ihnestrasse 63-73, D-1000 Berlin 33 (Dahlem), FRG |
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Abstract: | Summary Ribosomes from the thiostrepton-resistant mutant MJ1 of Bacillus megaterium completely lack a protein designated BM-L11. When assayed in vitro, such ribosomes show an impaired ability to hydrolyse GTP in the presence of the elongation factor EF-G and are unable to support the synthesis of (p)ppGpp in response to the stringent factor. Restoration of both these activities can be achieved by re-addition of either protein BM-L11 or its serological homologue from Escherichia coli, protein L11, implying that these two proteins are related functionally as well as immunologically. |
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