A new modification of anti-tubercular active molecules |
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| Authors: | Imramovský Ales Polanc Slovenko Vinsová Jarmila Kocevar Marijan Jampílek Josef Recková Zuzana Kaustová Jarmila |
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| Institution: | Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. imramovsky@faf.cuni.cz |
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| Abstract: | The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed. |
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