Preliminary crystallographic analysis of the Fab fragment of an antibody against HIV gp120. |
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| Authors: | M N Vyas N K Vyas R S Liou T W Chang F A Quiocho |
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| Institution: | Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030. |
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| Abstract: | Single crystals of the Fab fragment of a murine monoclonal antibody BAT123 (IgG1, kappa) raised against a dominant neutralizing determinant of gp120 of HIV that are suitable for X-ray structural analysis have been obtained. The thick prismatic plate crystals belong to space group P2(1)2(1)2 with unit cell dimensions of a = 177.42 A, b = 37.36 A and c = 73.30 A. |
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