Design and synthesis of novel chemokine analogs derived from vMIP-II |
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| Authors: | Wang Jun Kumar Santhosh Choi Won-Tak Dong Changzhi Huang Ziwei |
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| Affiliation: | Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. |
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| Abstract: | Stepwise solid phase synthesis using the Fmoc chemistry is reported for a panel of 71-residue and novel unnatural chemokine analogs derived from vMIP-II. This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors. |
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