Mass spectrometric analysis of the Schistosoma mansoni tegumental sub-proteome |
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| Authors: | van Balkom Bas W M van Gestel Renske A Brouwers Jos F H M Krijgsveld Jeroen Tielens Aloysius G M Heck Albert J R van Hellemond Jaap J |
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| Institution: | Department of Biomolecular Mass Spectrometry, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. B.W.M.vanBalkom@vet.uu.nl |
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| Abstract: | Schistosoma mansoni is a parasitic worm that lives in the blood vessels of its host. We mapped the S. mansoni tegumental outer-surface structure proteome by 1D SDS-PAGE and LC-MS/MS and an EST-database from the ongoing genome-sequencing project. We identified 740 proteins of which 43 were tegument-specific. Many of these proteins show no homology to any nonschistosomal protein, demonstrating that the schistosomal outer-surface comprises specific and unique proteins, likely to be critical for parasite survival. |
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