Exogenous hypercholesterolemic rats, compared with their progenitor, Sprague-Dawley rats, promptly alter cholesterol metabolism in the liver and secrete cholesterol-rich particles in response to dietary cholesterol |
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| Authors: | Masanobu Sakono Haruhiko Mori Koji Nagao Masao Sato Ikuo Ikeda Kyosuke Yamamoto Katsumi Imaizumi |
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| Affiliation: | ∗Laboratory of Nutrition Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka 812-81, Japan;†Department of Internal Medicine, Saga Medical School, Saga 849, Japan |
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| Abstract: | Early responses of cholesterol metabolism to dietary cholesterol were compared between exogenous hypercholesterolemic (ExHC) and Sprague-Dawley rats. Both strains had a similar radioactivity of [14C]cholesterol in the serum half a day after the oral administration, but thereafter the radioactivity disappeared slowly in ExHC rats. ExHC rats promptly altered in response to the dietary cholesterol, activities of cholesterol 7α-hydroxylase and cholesterol synthesis in the liver and fecal excretion of bile acids derived from [14C]cholesterol administered orally. Lymphatic transport for 24 hr of [14C]cholesterol was similar between the strains. Triton administration resulted in a marked accumulation of cholesterol in serum d > 1.006 g/ml lipoproteins in ExHC rats; in addition, the formation of cholesteryl esters from [14C]oleic acid intravenously infused was greater in ExHC rats. These results indicate that ExHC rats increase serum cholesterol in response to exogenous cholesterol by decreasing the liver uptake and enhancing the secretion in the liver. |
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| Keywords: | Exogenous hypercholesterolemic cholesterol secretion of lipoprotein 7α -hydroxylase cholesterol synthesis bile acids cholesteryl esters cholesterol uptake cholesterol absorption triacylglycerols |
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