Vanadate inhibition of rat cerebral cortex Na+, K+-ATPase during postnatal development |
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Authors: | Jaroslava Folbergrová Pavel Mareš |
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Affiliation: | (1) Institute of Physiology, Czechoslovak Academy of Sciences, Víde ská 1083, 142 20 Prague 4, Czechoslovakia |
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Abstract: | The Na+, K+-ATPase activity and its response to vanadate inhibition was investigated in cerebral cortex homogenates of 7-, 12- and 18-day-old rats. The enzyme was inhibited by vanadate in a dose-dependent manner in all these age groups. Furthermore, there was a different sensitivity towards vanadate during postnatal development; the concentration of V+5 needed for 50% inhibiton of Na+, K+-ATPase was 1.1×10–6M, 2×10–7M and 4.4×10–7M for 7-, 12- and 18-day-old rats, respectively. It is suggested that the different sensitivity of Na+, K+-ATPase towards vanadate inhibition during postnatal development might be due to age-dependent changes in the ratio of various cell types.Special Issue dedicated to Dr. O. H. Lowry. |
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Keywords: | Brain development Na+, K+-ATPase vanadate |
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