Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor |
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Authors: | Parker Janice C VanVolkenburg Maria A Gao Feng |
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Affiliation: | Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Groton CT 06340, USA. janice_c_parker@groton.pfizer.com |
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Abstract: | The effects on insulin secretion from INS-1 cells of varying concentrations of the sulfonylurea glyburide and the PDE3 inhibitor milrinone, separately and in combination were measured. Over a range of concentrations the effects of the two drugs in combination were more than additive. A response surface model was fit to the data and was found to describe the data well. From this model, it was apparent that a significant synergistic effect upon insulin secretion existed over a wide range of combinations of the two drugs. |
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Keywords: | Sulfonylurea Phosphodiesterase inhibitor Synergy Insulin secretion Bootstrap |
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