Honatisine, a novel diterpenoid alkaloid, and six known alkaloids from Delphinium honanense and their cytotoxic activity |
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Authors: | He Yang Qing Ma Zhan Ying Wei Xiao Mei Liu Dong Jie Du Bao Zhong Yao Bing Hua Gao Li Ming |
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Affiliation: | Department of Applied Chemistry, Xi'an University of Technology, Xi'an, P R China. hyq7978863@163.com |
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Abstract: | A novel diterpene alkaloid named honatisine (1) has been isolated from the whole plants of Delphinium honanense, along with six known alkaloids, siwanine E (2), isoatisine (3), atisine (4), delcorinine (5), uraphine (6), and nordhagenine A (7). Their structures were deduced on the basis of their spectral data. All of them were evaluated by a SRB assay for their cytotoxicity, and compound 1 showed a significant cytotoxic activity (IC(50) =3.16 μM) against the MCF-7 cell line. |
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Keywords: | Delphinium honanense Diterpene alkaloids Alkaloids Honatisine Cytotoxic activity |
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