New flavanones from the leaves of Cryptocarya chinensis and their antituberculosis activity |
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| Authors: | Chou Tsung-Hsien Chen Jih-Jung Peng Chien-Fang Cheng Ming-Jen Chen Ih-Sheng |
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| Institution: | Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. |
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| Abstract: | Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively. |
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| Keywords: | Flavanones Cryptoflavanones A – D Cryptocarya chinensis Antituberculosis activity |
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