Activation of autophagy is required for muscle homeostasis during physical exercise |
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Authors: | Nair Usha Klionsky Daniel J |
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Affiliation: | Life Sciences Institute; University of Michigan; Ann Arbor, MI USA |
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Abstract: | Skeletal muscle fibers of collagen VI null (Col6a12/2) mice show signs of degeneration due to a block in autophagy, leading to the accumulation of damaged mitochondria and excessive apoptosis. Attempts to induce autophagic flux by subjecting these mutant mice to long-term or shorter bursts of physical activity are unsuccessful (see Grumati, et al., pp. 1415–23). In normal mice, the induction of autophagy in the skeletal muscles post-exercise is able to prevent the accumulation of damaged organelles and maintain cellular homeostasis. Thus, these studies provide an important connection between autophagy and exercise physiology. |
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Keywords: | lysosome metabolism physiology stress vacuole |
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