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Synergistic interaction between particular X-chromosome deletions andSex-lethal causes female lethality inDrosophila melanogaster
Authors:Anuranjan Anand  H Sharat Chandra
Institution:1. Department of Microbiology and Cell Biology, Indian Institute of Science, 560 012, Bangalore, India
2. Jawaharlal Nehru Centre for Advanced Scientific Research, 560 012, Bangalore, India
Abstract:We studied the effect on female viability oftrans-heterozygous combinations of X-chromosome deficiencies andSxl f1, a null allele ofSex-lethal. Twentyfive deficiencies, which together covered 80% of the X chromosome, were tested. Seven of thesetrans-hcterozygous combinations caused significant levels of female lethality. Two of the seven interacting deficiencies include the previously known sex determination genessans fills andsisterless-a. Four of the remaining uncover X-chromosomal regions that were not hitherto known to contain sex determination genes. These newly identified regions are defined by deficienciesDf(1)RA2 (7D10; 8A4-5),DJ(1)KA14 (7F1-2; 8C6),Df(1)C52 (8E; 9C-D) andDf(1)NI9 (17A1; 18A2). These four deficiencies were characterized further to determine whether it was the maternal or zygotic dosage that was primarily responsible for the observed lethality of female embryos,daughterless andextra macrochaetae, two known regulators ofSxl, influence the interaction of these deficiencies withSxl.
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